abstract：BACKGROUND:A hyaluronan-loading test has been developed for assessment of hyaluronan kinetics and applied in patients with liver and joint diseases. This test describes the metabolic process of hyaluronan but cannot define the specific contribution of different organs. A method for labelling of hyaluronan with the shor...

journal_title：European journal of clinical investigation

authors： Lindqvist U,Westerberg G,Bergström M,Torsteindottir I,Gustafson S,Sundin A,Lööf L,Långström B

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Early detection of fungal infection is essential for beginning of prompt and specific therapy. In this study we describe a rapid and sensitive procedure to detect, by polymerase chain reaction (PCR) assays, a wide range of medically important opportunistic and pathogenic fungi in dermal specimens from dermat...

journal_title：European journal of clinical investigation

authors： Turin L,Riva F,Galbiati G,Cainelli T

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The role of the pattern, quantity and site of insulin secretion in the tolerance to a glucose challenge is not fully evaluated in humans because it is difficult to obtain appropriate clinical models. DESIGN:To address this issue, we studied subjects with reduced pancreatic mass (hemipancreatectomized, HEMI)...

journal_title：European journal of clinical investigation

authors： Battezzati A,Zerbi A,Perseghin G,Caumo A,Terruzzi I,Di Carlo V,Luzi L

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Little is known about gallbladder motility in patients with black pigment stones when compared to cholesterol gallstone patients, or about their relationship to biliary composition, crystallization and stone characteristics. DESIGN:Fasting and postprandial gallbladder volumes were studied by ultrasonography...

journal_title：European journal of clinical investigation

authors： Portincasa P,Di Ciaula A,Vendemiale G,Palmieri V,Moschetta A,Vanberge-Henegouwen GP,Palasciano G

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Immunosuppression associated with surgery may predispose to increased tumour growth or recurrence. Lymphocytes are central components of the immune network, signalling specific and non-specific responses in tumour immunosurveillance. This study was therefore designed to compare the effects of minimally invas...

journal_title：European journal of clinical investigation

authors： Leaver HA,Craig SR,Yap PL,Walker WS

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:To investigate the clinical features of thyroid cancer in aging patients and to present the results of treatment. From this we can provide bases for earlier diagnoses and better treatment of thyroid malignancies in older patients. MATERIALS AND METHODS:In this study a retrospective analysis was performed wi...

journal_title：European journal of clinical investigation

authors： Lin JD,Chao TC,Chen ST,Weng HF,Lin KD

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Morpholinosydnonimine, a nitric oxide (NO) donor, has been reported to inhibit insulin release in isolated pancreatic islets. We studied whether transdermal application of nitroglycerin, another NO donor widely used for angina prophylaxis, influenced glucose-stimulated insulin release in healthy, young, male...

journal_title：European journal of clinical investigation

authors： Kovacs P,Szilvassy Z,Hegyi P,Nemeth J,Ferdinandy P,Tosaki A

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Vitamin E supplementation is associated with a reduced risk of developing atherosclerotic events; probably because it inhibits low-density lipoprotein (LDL) oxidation, an initial step in atherosclerosis. Metal ion-dependent LDL oxidation is a commonly used method to estimate oxidizability of LDL, but the eff...

journal_title：European journal of clinical investigation

authors： Wen Y,Killalea S,Norris LA,Cooke T,Feely J

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Bleeding time has been reported to increase during gaseous nitric oxide (NO) inhalation in healthy volunteers and patients, and it has been speculated that inhaled NO inhibits platelet function. However, results have not been unanimous, and we have been unable to document any effects of inhaled NO on circula...

journal_title：European journal of clinical investigation

authors： Albert J,Norman M,Wallén NH,Frostell C,Hjemdahl P

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Early menopause, whether it be natural or surgical, is one of the established risk factors for osteoporosis. Surgical menopause, however, differs from natural menopause owing to the abrupt cessation of estrogen secretion. This study attempts to investigate the influence of menopause type on bone mineral dens...

journal_title：European journal of clinical investigation

authors： Hadjidakis D,Kokkinakis E,Sfakianakis M,Raptis SA

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNF) mRNA expression has been reported to be up-regulated in adipose tissue from several rodent models of obesity and diabetes and from obese humans. This elevated expression has been assumed to be associated with the development of insulin resistance. However, the biological si...

journal_title：European journal of clinical investigation

authors： Hube F,Birgel M,Lee YM,Hauner H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:In a previous study, we demonstrated the presence of receptors for somatostatin, a neuropeptide with immunoregulatory properties, in the inflammatory lesions of patients suffering from sarcoidosis and other granulomatous diseases by in vivo somatostatin receptor scintigraphy and in vitro autoradiography. How...

journal_title：European journal of clinical investigation

authors： ten Bokum AM,Hofland LJ,de Jong G,Bouma J,Melief MJ,Kwekkeboom DJ,Schonbrunn A,Mooy CM,Laman JD,Lamberts SW,van Hagen PM

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Changes in plasma leptin concentration and food intake occur during the menstrual cycle; because leptin regulates food intake, one could hypothesize that changes in plasma leptin concentration and in food intake are associated throughout the menstrual cycle. However, no data have ever been provided to suppor...

journal_title：European journal of clinical investigation

authors： Paolisso G,Rizzo MR,Mazziotti G,Rotondi M,Tagliamonte MR,Varricchio G,Carella C,Varricchio M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to ...

journal_title：European journal of clinical investigation

authors： Evsyukova HV

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Na+,K(+)-ATPase activity was evaluated in relation to membrane composition and molecular organization in erythrocyte membranes from obese patients by the amphyphylic molecule 6-dodecanoyl-2-dimethylamino-naphthalene (Laurdan). Its possible relationship with fat distribution and hyperinsulinaemia was also inv...

journal_title：European journal of clinical investigation

authors： Faloia E,Garrapa GG,Martarelli D,Camilloni MA,Lucarelli G,Staffolani R,Mantero F,Curatola G,Mazzanti L

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Our aim in the present study was to determine whether endothelial NO synthase gene (ecNOS) polymorphisms are associated with myocardial infarction (MI). METHODS:Forty chromosomes from patients with MI were screened for polymorphisms of the ecNOS gene using polymerase chain reaction-single-strand conformatio...

journal_title：European journal of clinical investigation

authors： Poirier O,Mao C,Mallet C,Nicaud V,Herrmann SM,Evans A,Ruidavets JB,Arveiler D,Luc G,Tiret L,Soubrier F,Cambien F

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Heparin-induced thrombocytopenia is a relatively uncommon but severe side-effect of heparin therapy. Heparin-induced IgG antibody has been elucidated to be the main isotype and the most pathogenic antibody in the pathophysiology. As affected patients are at high risk of developing thrombotic events, confirma...

journal_title：European journal of clinical investigation

authors： Wang LC,Huhle G,Malsch R,Hoffmann V,Song XL,Harenberg J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Diacylglycerols (DAGs), which are well-known components of insect lipophorins, have been recently recognized as a major glyceride of human high-density lipoprotein (HDL). Moreover, DAGs are good substrates for hepatic lipase and for the phospholipid transfer protein (PLTP). The present work was undertaken to...

journal_title：European journal of clinical investigation

authors： Lalanne F,Pruneta V,Bernard S,Ponsin G

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:To date it is not known whether gastric juice vitamin C levels are influenced by Helicobacter pylori CagA(+) strains. The aim of the present study, therefore, was to study the impact of H. pylori CagA status on gastric juice vitamin C levels. MATERIALS AND METHODS:We studied 30 H. pylori(+) patients, and th...

journal_title：European journal of clinical investigation

authors： Rokkas T,Liatsos C,Petridou E,Papatheodorou G,Karameris A,Ladas SD,Raptis SA

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The DALI low-density lipoprotein (LDL) apheresis system is the first whole-blood apheresis system in regular clinical use. DALI stands for direct adsorption of lipoproteins, which describes the basic principle of operation of this newly developed LDL apheresis procedure. METHODS:The selective removal of LDL...

journal_title：European journal of clinical investigation

authors： Dräger LJ,Julius U,Kraenzle K,Schaper J,Toepfer M,Zygan K,Otto V,Steinhagen-Thiessen E

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Chronic hyperglycaemia in diabetes is suggested to be a major cause of diabetic angiopathy. Up until now, the effects of acutely induced hyperglycaemia in non-diabetic subjects as well as hyperglycaemic effects in early diabetes, on mesenteric microcirculation and leucocyte endothelial cell interaction have ...

journal_title：European journal of clinical investigation

authors： Schäffler A,Arndt H,Schölmerich J,Palitzsch K

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Memory and cognitive functions are known to decline with advancing age. Studies have suggested that this may be due to a decrease in cholinergic function in the brains of elderly people. This review aims to assess studies documented in the literature dealing with the 'scopolamine model' of dementia. METHODS...

journal_title：European journal of clinical investigation

authors： Ebert U,Kirch W

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:In atherosclerosis, both reductions and elevations in plasma levels of antioxidants have been reported. This study investigated total antioxidant capacity of plasma from subjects with atherosclerotic disease. MATERIALS AND METHODS:The study population consisted of 48 men with or without carotid atherosclero...

journal_title：European journal of clinical investigation

authors： Reinisch N,Kiechl S,Mayr C,Schratzberger P,Dunzendorfer S,Kähler CM,Buratti T,Willeit J,Wiedermann CJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), a physiological inhibitor of the proliferation of haematopoietic stem cells, is degraded by the angiotensin-I-converting enzyme (ACE). Whereas synthetic AcSDKP (Goralatide) protects normal mice from the haematological toxicity of chemotherapy, it has a lower ...

journal_title：European journal of clinical investigation

authors： Comte L,Lorgeot V,Bignon J,Volkov L,Dupuis F,Wdzieczak-Bakala J,Praloran V

更新日期：1998-10-01 00:00:00

abstract：:Plasma glucose concentration is the best predictor for the development of non-insulin-dependent diabetes mellitus (NIDDM). However, obesity is also a recognized risk factor for development of the disease, and is easier to track over time. Thus obesity could be of considerable clinical importance as a predictor of diab...

journal_title：European journal of clinical investigation

authors： Ferrannini E,Camastra S

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:In mutations of the low-density lipoprotein (LDL) receptor gene, the defect of internalization is caused by a mutation in the cytoplasmic domain of the receptor linked with exons 17 and 18, and the O-linked sugar domain linked with exon 15 has been speculated not to affect the function of the receptor. Here,...

journal_title：European journal of clinical investigation

authors： Tashiro J,Endo M,Bujo H,Shinomiya M,Morisaki N,Saito Y

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The intestinal handling of dextran, an alpha-1,6-linked glucose polymer, is poor compared with starch, and some ingested dextran might therefore reach the lower small intestine. As luminal sugar up-regulates SGLT1 (sodium-dependent glucose transporter) locally, we report the effects of a dextran-enriched die...

journal_title：European journal of clinical investigation

authors： Debnam ES,Denholm EE,Grimble GK

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:The acute-phase response and anaemia of chronic disease are characterized by hypoferraemia associated with an increased ferritin synthesis, which might be mediated by the activated cytokine cascade. METHODS:We examined the prolonged effects of isolated limb perfusion (ILP) with recombinant human tumour necr...

journal_title：European journal of clinical investigation

authors： Feelders RA,Vreugdenhil G,Eggermont AM,Kuiper-Kramer PA,van Eijk HG,Swaak AJ

更新日期：1998-07-01 00:00:00

abstract：INTRODUCTION:Smoking is associated with dyslipidaemia, particularly raised plasma triglycerides and reduced high-density lipoprotein (HDL)-cholesterol and a delayed clearance of triglyceride in fat tolerance tests. The aim of this study was to investigate whether these phenomena could be explained by a reduced lipoprot...

journal_title：European journal of clinical investigation

authors： Freeman DJ,Caslake MJ,Griffin BA,Hinnie J,Tan CE,Watson TD,Packard CJ,Shepherd J

更新日期：1998-07-01 00:00:00

abstract：METHODS:Ten samples of decidua basalis from pre-eclamptic women and 10 from healthy primigravid women subjected to caesarean section (control tissues) were investigated immunohistochemically for changes in angiogenesis and expression of tenascin, an extracellular matrix protein thought to modulate angiogenesis. In addi...

journal_title：European journal of clinical investigation

authors： Ribatti D,Loverro G,Vacca A,Greco P,Roncali L,Selvaggi L

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Abnormal erythrocyte Na/Li countertransport is associated with diseases such as essential hypertension and diabetic renal disease. Although it seems unlikely that Na/Li countertransport contributes to any disease process, it may be abnormal because of a change in the cell membrane that is part of the disease...

journal_title：European journal of clinical investigation

authors： Thomas TH,Rutherford PA,Vareesangthip K,Wilkinson R,West IC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Low blood levels of antioxidants are associated with an increased risk of developing coronary artery disease. Lipophilic antioxidants are transported in lipoproteins, and hypolipidaemic therapy may therefore alter their blood concentrations. METHODS:The present randomized, placebo-controlled cross-over stud...

journal_title：European journal of clinical investigation

authors： Aberg F,Appelkvist EL,Bröijersén A,Eriksson M,Angelin B,Hjemdahl P,Dallner G

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Bezafibrate reportedly lowers serum lipids and plasma fibrinogen in humans and rats, but the mechanism of this process has still to be clarified. We have addressed this problem by investigating the effects of bezafibrate on fibrinogen in the human hepatoma HepG2 cell line. METHODS:In cells cultured with and...

journal_title：European journal of clinical investigation

authors： Binsack R,Stegmeier K,Dörge L,Völkl A

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Acute hyperglycaemia is known to inhibit jejunal interdigestive motility. This study was undertaken to establish the effects of hyperglycaemia on fed jejunal motility and small intestinal transit time, and to establish if the effects of hyperglycaemia are mediated in part by hyperinsulinaemia. METHODS:Nine ...

journal_title：European journal of clinical investigation

authors： Byrne MM,Pluntke K,Wank U,Schirra J,Arnold R,Göke B,Katschinski M

更新日期：1998-01-01 00:00:00

abstract：:Testosterone levels are decreased in obese men but increased in obese women. The interplay between gonadal steroids and leptin is, at present, far from being elucidated. This study was carried out to investigate the relationship between serum leptin, plasma insulin, insulin sensitivity and free testosterone in 46 men ...

journal_title：European journal of clinical investigation

authors： Vettor R,De Pergola G,Pagano C,Englaro P,Laudadio E,Giorgino F,Blum WF,Giorgino R,Federspil G

更新日期：1997-12-01 00:00:00

abstract：:The aim of this study was to assess the effect of intravenous dextran on bacterial translocation and intestinal vascular endothelial and epithelial barrier function after experimental partial hepatectomy. We determined systemic arterial pressure, enteric bacterial growth (proximal and distal small intestine and colon)...

journal_title：European journal of clinical investigation

authors： Wang XO,Sun ZW,Soltesz V,Deng XM,Andersson R

更新日期：1997-11-01 00:00:00

abstract：:Microdialysis was used to selectively assess the effect of the paracrine renin-angiotensin system (RAS) on interstitial glucose and lactate concentration profiles in skeletal muscle of healthy volunteers (n = 8) during basal and insulin-stimulated conditions. Paracrine RAS was selectively inhibited by local retrodialy...

journal_title：European journal of clinical investigation

authors： Müller M,Fasching P,Schmid R,Burgdorff T,Waldhäusl W,Eichler HG

更新日期：1997-10-01 00:00:00

abstract：:The pathogenesis of alcoholic fatty liver is unknown, but several causes have been proposed based on biochemical findings. These include the metabolism of alcohol leading to a shift in the cytosolic [NAD+]/ [NADH] ratio to reduction, which in turn causes a direct inhibition of beta-oxidation and enhanced triacylglycer...

journal_title：European journal of clinical investigation

authors： Eaton S,Record CO,Bartlett K

更新日期：1997-09-01 00:00:00

abstract：:We evaluated the influence of family history of hypertension on insulin sensitivity in lean and obese hypertensive subjects (H): 40 lean [body mass index (BMI) < or = 25 kg m-2] H with normotensive parents (F-), 50 lean H with one or two parents hypertensive (F+), 30 obese HF- (BMI > or = 30 kg m-2) and 35 obese HF+. ...

journal_title：European journal of clinical investigation

authors： Grandi AM,Gaudio G,Fachinetti A,Zanzi P,Bianchi L,Ceriani L,Guasti L,Venco A

更新日期：1997-09-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease associated with autoimmune disorders. The aetiology is unknown, although it has been suggested that the disease may be related to infectious agents. Previous studies revealed that sera from patients with PBC react against Mycobacterium gordonae. Th...

journal_title：European journal of clinical investigation

authors： Vilagut L,Parés A,Viñas O,Vila J,Jiménez de Anta MT,Rodés J

更新日期：1997-08-01 00:00:00